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Seminar with Nic Geard
Date: 28th July, 11am
Location: 78-621, GP South Title: Evolving Gene Regulatory Networks for Cellular Morphogenesis Authors: Tim Rudge and Nic Geard (presenting) Abstract: The generation of pattern and form in a developing organism results from a combination of interacting processes operating at different spatial and temporal scales. At the genetic level, networks of interacting genes set up and maintain complex patterns of gene expression across a field of cells. At a cellular level, physical processes such as cell growth and division generate shape the structure of those cells. The processes at both of these levels are tightly coupled: cellular events such as growth and division are under a degree of genetic control; and changes in cell structure result in changes to the inputs received by the genetic system within each cell. In this talk we present an integrated modeling framework for simulating multicellular morphogenesis that includes plausible models of both genetic and cellular processes, as well as an evolutionary component that allows us to search for interesting developmental systems. We are applying our modeling system to questions about the development of plant leaves - specifically, how do genetic and cellular processes interact to ensure that the development of leaves is robust to sources of environmental perturbation. We present the results of initial experiments performed using this framework and discuss some of the implications for complex systems in more general terms. A paper reporting this work has recently been submitted to the Second Australian Conference on Artificial Life. |
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